Murray has a strong interest in the dynamics and molecular mechanisms underpinning plant defense responses. He uses a combination of transcriptomics, targeted proteomics, real time imaging and metabolite profiling to develop a systems based understanding of the interrelated responses underpinning plant innate immunity, suppression of plant defenses and early signalling events that specify systemic immunity. An overriding theme is the dissection of the synergistic and antagonistic effects of phytohormones on disease and defense. Research predominately uses the Arabidopsis-Pseudomonas/Xanthomonas pathosystems. In collaboration with David Studholme and FERA at Sand Hutton, translational research programmes into Banana Xanthomonas Wilt in Central and Eastern Africa and Phytophthora ramorum infection of Japanese larch in UK forests are currently being initiated.